You’ll need a good holster that is designed to make carrying something like this full-sized pistol practical and comfortable.
I had to weigh in on this one as I've always insisted on carrying full size guns. I've carried a 5 inch TRP in 45 in my CCW mix for the last few years and have always been happy with my choice. If I have to go to the trouble to put at gun in holster, I'm going to carry the biggest gun I can. If I had one of these XDMs, I'd do the exact same thing as in that post. I use Milt Sparks holsters, though.